Niels Lorenzen

Niels Lorenzen

Professor

DTU AQUA
National Institute of Aquatic Resources

Public Sector Consultancy

Technical University of Denmark

Kemitorvet

Building 204, room 137

2800 Kgs. Lyngby

Request a vCard via e-mail.

Publications
Projects
Loading

Publications rss feed

2019
 

Pichia pastoris yeast as a vehicle for oral vaccination of larval and adult teleosts

Embregts, Carmen W.E. ; Reyes-Lopez, Felipe ; Pall, Adina C. ; Stratmann, Ansgar ; Tort, Luis ; Lorenzen, Niels ; Engell-Sorensen, Kirsten ; Wiegertjes, Geert F. ; Forlenza, Maria ; Sunyer, J. Oriol ; Parra, David
in: Fish and Shellfish Immunology, vol: 85, pages: 52-60

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2018.07.033

 

A pentavalent vaccine for rainbow trout in Danish aquaculture

Marana, Moonika H ; Sepulveda Araneda, Dagoberto Andres ; Chen, Defang ; Al-Jubury, Azmi ; Jaafar, Rzgar M ; Kania, Per W ; Henriksen, Niels Henrik ; Krossøy, Bjørn ; Dalsgaard, Inger ; Lorenzen, Niels ; Buchmann, Kurt
in: Fish and Shellfish Immunology, vol: 88, pages: 344-351

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2019.03.001

 

A recombinant vaccine targeting the parasitic ciliate Ichthyophthirius multifiliis

Jorgensen, L. V. G. ; Kania, P. W. ; Araneda, D. A. S. ; Lorenzen, Niels ; Stratmann, A. ; Buchmann, Kurt
in: Fish and Shellfish Immunology, vol: 91, pages: 405-406

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2019.04.114

  PDF

A recombinant vaccine targeting the parasitic ciliate Ichthyophthirius multifiliis

Jørgensen, Louise von Gersdorff ; Kania, Per ; Sepúlveda, Dagoberto ; Lorenzen, Niels ; Stratmann, Ansgar ; Buchmann, Kurt
Presented at:
The 8th Congress of the Scandinavian-Baltic Society for Parasitology

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2019

 

Demonstration of herd immunity effects in dna vaccinated rainbow trout

Lorenzen, N. ; Lorenzen, E. ; Rasmussen, J. S. ; Kjær, T. E. ; Einer-Jensen, K.
in: Fish and Shellfish Immunology, vol: 91, pages: 423-423
Presented at:
3rd International Conference of Fish and Shellfish Immunology

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2019.04.160

 

DNA vaccination for finfish aquaculture

Collins, Catherine ; Lorenzen, Niels ; Collet, Bertrand
in: Fish and Shellfish Immunology, vol: 85, pages: 106-125

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2018.07.012

  PDF

New Tools to Improve Fish Health and Environment in Organic Aquacultur

Jokumsen, Alfred ; Gesto, Manuel ; Buchmann, K. ; Lorenzen, Niels ; Pedersen, Lars-Flemming ; Henriksen, N. H. ; Schmidt, Jacob Günther ; Madsen, Lone ; Kania, Per ; Pedersen, Per Bovbjerg
Presented at:
Aquaculture Europe 2019

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2019

  PDF

Preface to the Special Issue 'Targeting Fish vaccination'

Wiegertjes, Geert ; Lorenzen, Niels ; Tafalla, Carolina
in: Fish and Shellfish Immunology, vol: 85, pages: 1-2

Type: Comment/debate (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2018.09.048

 

Recombinant immunotherapy against Ichthyophthirius multifiliis in Oncorhynchus mykiss

Sepulveda, Dagoberto ; Clarke, Theodore G. ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 91, pages: 398-399

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2019.04.095

  PDF

Time-course study of the protection induced by an interferon-inducible DNA vaccine against viral haemorrhagic septicaemia in rainbow trout

Sepúlveda, Dagoberto ; Lorenzen, Ellen ; Rasmussen, Jesper Skou ; Einer-Jensen, Katja ; Collet, Bertrand ; Secombes, C. J. ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 85, pages: 99-105

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.fsi.2018.06.056

2018
 

Virulence marker candidates in N-protein of viral haemorrhagic septicaemia virus (VHSV): virulence variability within VHSV Ib clones

Ito, Takafumi ; Kurita, Jun ; Mori, Koh-ichiro ; Skall, Helle Frank ; Lorenzen, Niels ; Vendramin, Niccolò ; Andersen, Nikolaj Gedsted ; Einer-Jensen, Katja ; Olesen, Niels Jørgen
in: Diseases of Aquatic Organisms, vol: 128, issue: 1, pages: 51-62

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.3354/dao03215

2017
  PDF

Intramuscular DNA Vaccination of Juvenile Carp against Spring Viremia of Carp Virus Induces Full Protection and Establishes a Virus-Specific B and T Cell Response

Embregts, Carmen W. E. ; Rigaudeau, Dimitri ; Veselý, Tomas ; Pokorová, Dagmar ; Lorenzen, Niels ; Petit, Jules ; Houel, Armel ; Dauber, Malte ; Schütze, Heike ; Boudinot, Pierre ; Wiegertjes, Geert F. ; Forlenza, Maria
in: Frontiers in Immunology, vol: 8

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.3389/fimmu.2017.01340

2015
 

Involvement of two microRNAs in the early immune response to DNA vaccination against a fish rhabdovirus

Bela-ong, Dennis Berbulla ; Schyth, Brian Dall ; Zou, Jun ; Secombes, Christopher J. ; Lorenzen, Niels
in: Vaccine, vol: 33, issue: 28, pages: 3215-3222

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1016/j.vaccine.2015.04.092

2014
 

High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv

Einer-Jensen, Katja ; Harmache, Abdallah ; Biacchesi, Stéphane ; Bremont, Michel ; Stegmann, Anders ; Lorenzen, Niels
in: Journal of General Virology, vol: 95, issue: Pt 2, pages: 307-316

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1099/vir.0.057448-0

2013
  PDF

Antiviral immunity in fish – functional analysis using DNA vaccination as a tool

Lorenzen, Niels ; Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; LaPatra, S. E.
part of: DAFINET Workshop and Ph.D. Course, 2013, DAFINET
Presented at:
DAFINET Workshop : Diagnosis and Control of Fish Diseases

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2013

 

DNA vaccination in fish promotes an early chemokine-related recruitment of B cells to the muscle

Castro, R. ; Martínez-Alonso, S. ; Fischer, U. ; Álvarez de Haro, N. ; Soto-Lampe, V. ; Lorenzen, Niels ; Lorenzen, Ellen ; Wang, T. ; Secombes, C. J. ; Tafalla, C.
in: Fish and Shellfish Immunology, vol: 34, issue: 6, pages: 1643
Presented at:
1st International Conference of Fish and Shellfish Immunology (VIGO 2013)

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1016/j.fsi.2013.03.028

  PDF

Do microRNAs induced by Viral Hemorrhagic Septicemia virus in rainbow trout (Oncorhynchus mykiss) possess anti-viral activity?

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
part of: DAFINET Workshop and Ph.D. Course, 2013, DAFINET
Presented at:
DAFINET Workshop : Diagnosis and Control of Fish Diseases

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2013

 

Evaluation of the potential anti-viral activity of microRNAs in rainbow trout (Oncorhynchus mykiss)

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 34, issue: 6, pages: 1639-1639
Presented at:
1st International Conference of Fish and Shellfish Immunology (VIGO 2013)

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1016/j.fsi.2013.03.016

  PDF

Evaluation of the potential roles of microribonucleic acids in the interaction of rainbow trout (Oncorhynchus mykiss) with Viral hemorrhagic septicemia virus

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
16th International Conference on Diseases of Fish and Shellfish

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2013

 

Inter-species transmission of viral hemorrhagic septicemia virus (VHSV) from turbot (Scophthalmus maximus) to rainbow trout (Onchorhynchus mykiss)

Schönherz, Anna Amanda ; Lorenzen, Niels ; Einer-Jensen, Katja
in: Journal of General Virology, vol: 94, issue: 4, pages: 869-875

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1099/vir.0.048223-0

 

MicroRNA expression in rainbow trout (Oncorhynchus mykiss) vaccinated with a DNA vaccine encoding the glycoprotein gene of Viral hemorrhagic septicemia virus

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
7th International Conference and Exhibition on Gene Regulation by Small RNAs (RNAi 2012)

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2013

  PDF

Of Fish and Micrornas

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
17th Annual Workshop of the National Reference Laboratories for Fish Diseases

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2013

  PDF

Rhabdoviruss-Induced Fish-Specific Microribonucleic Acids in Rainbow Trout (Oncorhynchus Mykiss)

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
European Molecular Biology Organization/European Molecular Biology Laboratory (EMBO/EMBL) Symposium on The Non-Coding Genome

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2013

 

Testing the ability of viral haemorrhagic septicaemia virus to evade the protective immune response induced in rainbow trout by DNA vaccination

Sepulveda, Dagoberto ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 34, issue: 6, pages: 1737-1737
Presented at:
1st International Conference of Fish and Shellfish Immunology (VIGO 2013)

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1016/j.fsi.2013.03.310

 

Use of DNA vaccination for determination of onset of adaptive immunity in rainbow trout fry

Rasmussen, Jesper Skou ; Lorenzen, Ellen ; Kjær, Torben Egil ; Einer-Jensen, Katja ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 34, issue: 6, pages: 1674-1674
Presented at:
1st International Conference of Fish and Shellfish Immunology (VIGO 2013)

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1016/j.fsi.2013.03.125

 

Whole inactivated virus vaccine prototype protects against viral encephalopathy and retinopathy in european sea bass (D.labrax)

Borghesan, F. ; Vendramin, Niccolò ; Bovo, G. ; Quartesan, R. ; Cappellozza, E. ; Lorenzen, Niels ; Terregino, C. ; Toffan, A.
part of: 16th International Conference on Diseases of Fish and Shellfish, pages: 124, 2013, European Association of Fish Pathologists
Presented at:
16th International Conference on Diseases of Fish and Shellfish

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2013

2012
 

Chemical modification of RNA-based medicine can be used to reduce its induction of the innate immune response

Schyth, Brian Dall ; Bramsen, Jesper Bertram ; Kjems, Jørgen ; Wengel, Jesper ; Lorenzen, Niels
part of: DAFINET Workshop, 2012, Danish Fish Immunology Research Centre and Network
Presented at:
DAFINET Workshop

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2012

  PDF

Determining Vaccination Frequency in Farmed Rainbow Trout Using Vibrio anguillarum O1 Specific Serum Antibody Measurements

Holten-Andersen, Lars ; Dalsgaard, Inger ; Nylén, Jørgen ; Lorenzen, Niels ; Buchmann, Kurt
in: P L o S One, vol: 7, issue: 11, pages: e49672

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1371/journal.pone.0049672

 

DNA vaccination of small rainbow trout fry against VHSV

Rasmussen, Jesper Skou ; Lorenzen, Ellen ; Kjær, Torben Egil ; Einer-Jensen, Katja ; Lorenzen, Niels
part of: DAFINET Workshop, 2012, Danish Fish Immunology Research Centre and Network
Presented at:
DAFINET Workshop

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2012

 

Efficacy of a glycoprotein DNA vaccine against viral haemorrhagic septicaemia (VHS) in Pacific herring, Clupea pallasii Valenciennes

Hart, L. M. ; Lorenzen, Niels ; LaPatra, S. E. ; Grady, C. A. ; Roon, S. E. ; O’Reilly, J. ; Gregg, J. L. ; Hershberger, P. K.
in: Journal of Fish Diseases Online, vol: 35, issue: 10, pages: 775-779

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1111/j.1365-2761.2012.01364.x

 

Expression of micro-RNAs and immune-relevant genes in rainbow trout (Oncorhynchus mykiss Walbaum) upon vaccination with a Viral Haemorrhagic Septicemia Virus

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
part of: DAFINET Workshop, 2012, Danish Fish Immunology Research Centre and Network
Presented at:
DAFINET Workshop

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2012

  PDF

Expression of microRNAs and interferon-related genes in rainbow trout (Oncorhynchus mykiss Walbaum) infected with Viral hemorrhagic septicemia virus

Bela-Ong, Dennis ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
International Workshop on Small RNAs in Cancer, Inflammation, and Aging

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2012

 

Improved Protection of Rainbow Trout Against Furunculosis by an Autologous Vaccine Under Experimental Conditions

Lorenzen, Ellen ; Kjær, Torben Egil ; Henriksen, Niels Henrik ; Dalsgaard, Inger ; Holten-Andersen, Lars ; Madsen, S. B. ; Krossøy, B. ; Buchmann, Kurt ; Lorenzen, Niels
part of: DAFINET Workshop : Immune Responses in Fish, pages: 20, 2012, University of Copenhagen
Presented at:
DAFINET Workshop : Immune Responses in Fish

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2012

 

Inter-Species Transmission of Viral Haemorrhagic Septicaemia Virus Between Turbot (Scophthalmus Maximus) and Rainbow Trout (Onchorhynchus Mykiss)

Schönherz, A. A. ; Lorenzen, Niels ; Einer-Jensen, Katja
part of: DAFINET Workshop : Immune Responses in Fish, pages: 24, 2012, University of Copenhagen
Presented at:
DAFINET Workshop : Immune Responses in Fish

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2012

  PDF

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Schyth, Brian Dall ; Bramsen, Jesper Bertram ; Pakula, Malgorzata Maria ; Larashati, Sekar ; Kjems, Jørgen ; Wengel, Jesper ; Lorenzen, Niels
in: Nucleic Acids Research, vol: 40, issue: 10, pages: 4653-4665

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1093/nar/gks033

 

Oral transmission as a route of infection for viral haemorrhagic septicaemia virus in rainbow trout, Oncorhynchus mykiss (Walbaum)

Schönherz, Anna Amanda ; Hansen, M. H. H. ; Jørgensen, H. B. H. ; Berg, P. ; Lorenzen, Niels ; Einer-Jensen, Katja
in: Journal of Fish Diseases Online, vol: 35, issue: 6, pages: 395-406

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1111/j.1365-2761.2012.01358.x

 

Typing of viral hemorrhagic septicemia virus by monoclonal antibodies

Ito, Takafumi ; Kurita, Jun ; Sano, Motohiko ; Skall, Helle Frank ; Lorenzen, Niels ; Einer-Jensen, Katja ; Olesen, Niels Jørgen
in: Journal of General Virology, vol: 93, issue: Pt 12, pages: 2546-2557

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1099/vir.0.043091-0

2011
 

Assessment of the Epitope Specificity of Monoclonal Antibodies that can Discriminate between the Various Genotypes of VHSV

Ito, T. ; Kurita, J. ; Sano, M. ; Skall, Helle Frank ; Lorenzen, Niels ; Olesen, Niels Jørgen
Presented at:
8th International Symposium on Viruses of Lower Vertebrates

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

  PDF
  PDF

Correlation of mRNA Profiles, miRNA Profiles, and Functional Immune Response in Rainbow Trout (Oncorrhynkus Mykiss) Infected With Viral Hemorrhagic Septicemia Virus (VHSV) and in Fish Vaccinated With a DNA Vaccine Against VHSV

Bela-Ong, Dennis ; Schyth, Brian Dall ; Jørgensen, Hanne ; Hansen, Mette H. ; Henryon, Mark ; Berg, Peer ; Lorenzen, Niels
part of: Book of abstracts, 2011, DAFINET, Frederiksberg
Presented at:
DAFINET Workshop : Immune Response in Early Stages of Development of Fish

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Epizone: Interlaboratory Ring Trial to Compare Dna Transfection Efficiencies

Dory, Daniel ; Albina, Emmanuel ; Kwiatek, Olivier ; Keil, Guenther ; Finke, Stefan ; Fuchs, Walter ; Kluup, Barbara ; König, Patricia ; Dixon, Linda ; Goatley, Lynnette ; Takamatsu, Haru ; Borrego, Belen ; Brun, Alejandro ; Ortego, Javier ; Friis, Martin Barfred ; Lorenzen, Niels ; Rasmussen, Thomas Bruun ; Schyth, Brian Dall ; Crooke, Helen ; Sosan, Olbukola
Presented at:
5th Annual Meeting EPIZONE

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

 

General and family-specific gene expression responses to viral hemorrhagic septicaemia virus infection in rainbow trout (Oncorhynchus mykiss)

Jørgensen, H. B. H. ; Sørensen, P. ; Cooper, G. A. ; Lorenzen, Ellen ; Lorenzen, Niels ; Hansen, M. H. H. ; Koop, B. F. ; Henryon, M.
in: Molecular Immunology, vol: 48, issue: 8, pages: 1046-1058

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1016/j.molimm.2011.01.014

  PDF

Gene regulatory mechanisms in infected fish

Schyth, Brian Dall ; Hajiabadi, Seyed Amir Hossein Jalali ; Kristensen, Lasse Bøgelund Juel ; Lorenzen, Niels
part of: DAFINET Workshop, 2011
Presented at:
DAFINET Workshop

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Inhibition of Reporter Genes by Small Interfering RNAs in Cell Culture and Living Fish

Larashati, Sekar ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
15th International Conference on Diseases of Fish and Shellfish

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Inhibition of Reporter Genes by Small Interfering RNAs in Cell Culture and Living Fish

Larashati, Sekar ; Schyth, Brian Dall ; Lorenzen, Niels
part of: Book of abstracts, 2011, DAFINET, Frederiksberg
Presented at:
DAFINET Workshop : Immune Response in Early Developmental Stages of Fish

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

microRNA regulation in rainbow trout infected with a fish pathogenic rhabdovirus

Schyth, Brian Dall ; Hajiabadi, Seyed Amir Hossein Jalali ; Kristensen, Lasse Bøgelund Juel ; Pedersen, Finn Skou ; Lorenzen, Niels
Presented at:
Keystone Symposium on Mechanisms and Biology of Silencing

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

 

Rainbow trout surviving infections of viral haemorrhagic septicemia virus (VHSV) show lasting antibodies to recombinant G protein fragments

Encinas, P. ; Gomez-Casado, E. ; Grandes, Fregeneda ; Olesen, Niels Jørgen ; Lorenzen, Niels ; Estepa, A. ; Coll, J. M.
in: Fish and Shellfish Immunology, vol: 30, issue: 3, pages: 929-935

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1016/j.fsi.2011.01.021

  PDF

Recombinant hybrid infectious hematopoietic necrosis virus (IHNV) carrying viral haemorrhagic septicaemia virus (VHSV) G or NV genes show different virulence properities

Einer-Jensen, Katja ; Biacchesi, S. ; Stegmann, Anders ; Bremont, M. ; Lorenzen, Niels
Presented at:
15th International Conference on Diseases of Fish and Shellfish

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Search for genetic virulence markers in viral haemorrhagic septicaemia virus (VHSV) using a reverse genetics approach

Stegmann, Anders ; Biacchesi, S. ; Bremont, M. ; Lorenzen, Niels ; Einer-Jensen, Katja
Presented at:
15th International Conference on Diseases of Fish and Shellfish

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Small regulatory RNAs of the RNA interference (RNAi) pathway as a prophylactic treatment against fish pathogenic viruses

Schyth, Brian Dall ; Hajiabadi, Seyed Amir Hossein Jalali ; Kristensen, Lasse Bøgelund Juel ; Lorenzen, Niels
part of: Abstracts - 5th Annual Meeting EPIZONE, 2011
Presented at:
5th Annual Meeting EPIZONE

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2011

  PDF

Temperature influences the expression profiling of immune response genes in rainbow trout following DNA vaccination and VHS virus infection

Einer-Jensen, Katja ; Gautier, Laurent ; Rasmussen, Jesper Skou ; Lorenzen, Ellen ; Christensen, Mikkel Black ; Villanueva, Sara A. ; Martin, Samuel ; Evensen, Øystein ; Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
Joint Western Fish Disease Workshop & AFS fish Health Section meeting

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2011

 

The Protective Mechanisms Induced by a DNA Vaccine in Fish Depend on Temperature

Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Christensen, Mikkel Black ; Collet, B. ; Secombes, C. J. ; Lorenzen, Niels
in: Scandinavian Journal of Immunology, vol: 73, issue: 4, pages: 392-392

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2011

 

Viral haemorrhagic septicaemia virus (VHSV) in rainbow trout: virulence variability within genotype Ib isolates

Ito, T. ; Kurita, J. ; Skall, Helle Frank ; Lorenzen, Niels ; Olesen, Niels Jørgen
Presented at:
15th International Conference on Diseases of Fish and Shellfish

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2011

2010
 

Cellular and molecular immune responses of the sea bass (Dicentrarchus labrax) experimentally infected with betanodavirus

Scapigliati, G. ; Buonocore, F. ; Randelli, E. ; Casani, D. ; Meloni, S. ; Zarletti, G. ; Tiberi, M. ; Pietretti, D. ; Boschi, I. ; Manchado, M. ; Martin-Antonio, B. ; Jimenez-Cantizano, R. ; Bovo, G. ; Borghesan, F. ; Lorenzen, Niels ; Einer-Jensen, Katja ; Adams, S. ; Thompson, K. ; Alonso, C. ; Bejar, J. ; Borrego, J.J. ; Alvarez, M.C.
in: Fish and Shellfish Immunology, issue: 28, pages: 303-311

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1016/j.fsi.2009.11.008

  PDF

Experimental vaccination of small turbot against bacterial and viral pathogens

Lorenzen, Ellen ; Rasmussen, Jesper Skou ; Kjær, Torben Egil ; Einer-Jensen, Katja ; Engell-Sørensen, K. ; Dalsgaard, Inger ; Nylén, J. ; Buchmann, K. ; Lorenzen, Niels
Presented at:
Dafinet-Scofda workshop

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

 

Expression Profiling of Immune Response Genes in Rainbow Trout Following DNA Vaccination and VHS Virus Infection

Rasmussen, Jesper Skou ; Christensen, Mikkel Black ; Einer-Jensen, Katja ; Lorenzen, Ellen ; Lorenzen, Niels
Presented at:
Symposium of the European Organisation of Fish Immunology

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2010

 

Identification of Genetic Virulence Markers in VHS Virus

Stegmann, Anders ; Lorenzen, Niels ; Bremont, M. ; Einer-Jensen, Katja
Presented at:
8th International Symposium on Viruses of Lower Vertebrates

Type: Poster

Status: Published     |    Year: 2010

 

Immersion exposure of rainbow trout (Oncorhynchus mykiss) fry to wildtype Flavobacterium psychrophilum induces no mortality, but protects against later intraperitoneal challenge

Lorenzen, Ellen ; Brudeseth, B.E. ; Wiklund, T. ; Lorenzen, Niels
in: Fish and Shellfish Immunology, vol: 28, issue: 3, pages: 440-444

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1016/j.fsi.2009.11.025

 

In vivo screening of backbone modified siRNAs for their ability to induce interferon based off-target effects

Schyth, Brian Dall ; Bramsen, Jesper Bertram ; Kjems, Jørgen ; Wengel, Jesper ; Lorenzen, Niels
Presented at:
RNAi

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

 

N-Linked Glycans on the Viral Glycoprotein are not Required for Induction of Protective Immunity to VHSV when Delivered as a DNA Vaccine

Einer-Jensen, Katja ; Lorenzen, Ellen ; Rasmussen, Jesper Skou ; Lorenzen, Niels
Presented at:
8th International Symposium on Viruses of Lower Vertebrates

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

 

Protection Against Viral Haemorrhagic Septicemia Virus (VHSV) in Rainbow Trout Using a DNA Vaccine with MX1 Promotor Controlled Expression of the Viral G Protein

Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Collet, B. ; Secombes, C. ; Lorenzen, Ellen ; Lorenzen, Niels
Presented at:
Symposium of the European Organisation of Fish Immunology

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

 

Studies on herd-immunity and primary versus secondary infection of VHSV in challenge and vaccination trials with rainbow trout

Lorenzen, Ellen ; Kjær, Torben Egil ; Lorenzen, Niels
Presented at:
Symposium of the European Organization of Fish Immunology

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

  PDF

Temperature effects on vaccine induced immunity to viruses in fish

Lorenzen, Niels ; Lorenzen, Ellen ; Rasmussen, Jesper Skou ; Christensen, Mikkel Black ; Einer-Jensen, Katja ; Veselý, T. ; Poroková, D.
Presented at:
8th International Symposium on Viruses of Lower Vertebrates

Type: Conference abstract for conference

Status: Published     |    Year: 2010

 

Using small interfering RNAs (siRNAs) to combat a fish pathogenic virus

Schyth, Brian Dall ; Lorenzen, Niels
Presented at:
4th Annual Meeting EPIZONE

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2010

 

Viral diseases of fish and a possible role for small regulatory RNAs in their antiviral defence

Schyth, Brian Dall ; Jalali, Seyed Amir Hossein ; Kristensen, Lasse Bøgelund Juel ; Lorenzen, Niels
Presented at:
Theme 5 Annual Meeting : Intervention Strategies

Type: Conference abstract for conference

Status: Published     |    Year: 2010

2009
  PDF

Adptive versus innate immune mechanisms in trout responding to rhabdovirus antigens.

Lorenzen, Niels
Presented at:
Dafinet & Scofda Symposium

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

Distinction of genotypes of viral haemorrhagic septicaemia virus (VHSV) by monoclonal antibodies

Ito, Takafumi ; Kurita, J. ; Sano, M. ; Skall, Helle Frank ; Lorenzen, Niels ; Olesen, Niels Jørgen
Presented at:
14th EAFP International Conference on Diseases of Fish and Shellfish

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

DNA Vaccines against Viral Diseases

Lorenzen, Niels ; Lorenzen, Ellen ; Rasmussen, Jesper Skou ; Einer-Jensen, Katja
in: Gyobyo Kenkyu, vol: 44, issue: 1, pages: 16-18
Presented at:
5th International Symposium of the Japanese-Society-of-Fish-Pathology

Type: Conference article (Peer reviewed)

Status: Published     |    Year: 2009

 

Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection

Einer-Jensen, Katja ; Delgado, L. ; Lorenzen, Ellen ; Bovo, G. ; Evensen, Ø. ; LaPatra, S. ; Lorenzen, Niels
in: Vaccine, vol: 27, issue: 8, pages: 1248-1253

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009     |    DOI: https://doi.org/10.1016/j.vaccine.2008.12.007

  PDF

Functional demonstration of adaptive immunity in zebrafish using DNA vaccination.

Lorenzen, Niels ; Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Kjær, Torben Egil ; Vesely, Thomas
Presented at:
Scofda and Dafinet Symposium 2009

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

Genetic and serological typing of European infectious haematopoietic necrosis virus (IHNV) isolates

Johansson, Tove ; Einer-Jensen, Katja ; Batts, William ; Ahrens, Peter ; Kurath, Gael ; Björklund, Harry ; Lorenzen, Niels
in: Diseases of Aquatic Organisms, vol: 86, issue: 3, pages: 213-221

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009     |    DOI: https://doi.org/10.3354/dao02108

  PDF

Interference of an ERM-vaccine with a VHS-DNA vaccine in rainbow trout

Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Lorenzen, Niels ; Ellis, Tony ; McLauchlan, Pamela ; Evensen, Øystein
Presented at:
The ontogeny of the fish immune system : Abildgaard Symposium & Research School Scofda

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

In Vivo Screening of Chemically Modified RNA duplexes for their Ability to Induce Innate Immune Responses

Schyth, Brian Dall ; Bramsen, Jesper Bertram ; Kjems, Jørgen ; Wengel, Jesper ; Lorenzen, Niels
Presented at:
4th International Conference RNAi2009 : ncRNA: Bridging Biology and Therapy

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2009

  PDF

IN VIVO SCREENING OF CHEMICAL MODIFICATIONS OF siRNAs FOR EFFECT ON THE INNATE IMMUNE RESPONSE IN FISH

Lorenzen, Niels ; Schyth, Brian Dall ; Bramsen, J. B. ; Kjems, J. ; Wengel, J.
Presented at:
11th Congress of the International Society of Developmental and Comparative Immunology (ISDCI)

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2009

  PDF

Kan nye VHS udbrud i regnbueørred forebygges ved vaccination eller avl?

Lorenzen, Niels
Presented at:
Workshop om projektet "Fiskevelfærd"

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

MicroRNA Expression during Viral Infection or PolyI:C Stimulation in a Fish Model

Kristensen, Lasse Bøgelund Juel ; Schyth, Brian Dall ; Lorenzen, Niels ; Pedersen, Finn Skou
Presented at:
MicroRNA : MicroRNA research results, technology insights and networking

Type: Poster

Status: Published     |    Year: 2009

 

New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus

Ruiz, S. ; Schyth, Brian Dall ; Encinas, P. ; Tafalla, Carolina ; Estepa, Amparo ; Lorenzen, Niels ; Coll, Julio
in: Antiviral Research, vol: 82, issue: 3, pages: 148-156

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009     |    DOI: https://doi.org/10.1016/j.antiviral.2009.02.200

 

O-114: Distinction between genotypes of viral haemorrhagic septicaemia virus (VHSV) using monoclonal antibodies

Ito, Takafumi ; Kurita, J. ; Sano, M. ; Iida, T. ; Skall, Helle Frank ; Lorenzen, Niels ; Olesen, Niels Jørgen
part of: 14th EAFP International Conference of Diseases of Fish and Shellfish, 2009, European Association of Fish Pathologists
Presented at:
14th EAFP International Conference on Diseases of Fish and Shellfish

Type: Conference abstract in proceedings

Status: Published     |    Year: 2009

 

Screening of Modified RNA duplexes

Schyth, Brian Dall ; Bramsen, Jesper Bertram ; Kjems, Jørgen ; Wengel, Jesper ; Lorenzen, Niels
Presented at:
RNA interference Summit

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2009

  PDF

Studies on herd-immunity and primary versus secondary infection of VHSV in challenge and vaccination trials with rainbow trout

Lorenzen, Ellen ; Kjær, Torben Egil ; Lorenzen, Niels
Presented at:
Scofda and Dafinet Symposium 2009

Type: Conference abstract for conference

Status: Published     |    Year: 2009

 

The protective mechanisms induced by a fish rhabdovirus DNA vaccine depend on temperature

Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Kjær, Torben Egil ; Collet, B. ; Secombes, C.J. ; Lorenzen, Niels
in: Vaccine, vol: 27, issue: 29, pages: 3870-3880

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009     |    DOI: https://doi.org/10.1016/j.vaccine.2009.04.012

  PDF

THE PROTECTIVE MECHANISMS INDUCED BY A FISH RHABDOVIRUS DNA-VACCINE DEPENDS ON TTEMPERATURE

Lorenzen, Niels ; Lorenzen, Ellen ; Einer-Jensen, Katja ; Rasmussen, Jesper Skou ; Kjær, Torben Egil ; Collet, Bertrand ; Secombes, Chris J.
Presented at:
11th Congress of the International Society of Developmental and Comparative Immunology (ISDCI)

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2009

2008
 

Cell-mediated immune responses in rainbow trout after DNA immunization against the viral hemorrhagic septicemia virus

Utke, Katrin ; Kock, Holger ; Schuetze, Heike ; Bergmann, Sven M. ; Lorenzen, Niels ; Einer-Jensen, Katja ; Köllner, Bernd ; Dalmo, Roy A. ; Vesely, Tomas ; Ototake, Mitsuru ; Fischer, Uwe
in: Developmental & Comparative Immunology, vol: 32, issue: 3, pages: 239-252

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2008     |    DOI: https://doi.org/10.1016/j.dci.2007.05.010

 

Regnbueørredens redning

Vinge, Thomas ; Lorenzen, Niels
in: Dynamo, issue: 12, pages: 28-31

Type: Journal article

Status: Published     |    Year: 2008

2007
 

A High Throughput In Vivo Model for Testing Delivery and Antiviral Effects of siRNAs in Vertebrates

Schyth, Brian Dall ; Lorenzen, Niels ; Pedersen, Finn Skou
in: Molecular Therapy, vol: 15, issue: 7, pages: 1366-72

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2007     |    DOI: https://doi.org/10.1038/sj.mt.6300150

 

Cell-mediated cytotoxicity in rainbow trout, Oncorhynchus mykiss, infected with viral haemorrhagic septicaemia virus

Utke, K. ; Bergmann, S. ; Lorenzen, Niels ; Kollner, B. ; Ototake, M. ; Fischer, U.
in: Fish and Shellfish Immunology, vol: 22, issue: 3, pages: 182-196

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2007     |    DOI: https://doi.org/10.1016/j.fsi.2006.04.008

 

Classification of viral haemorrhagic septicaemia virus (VHSV) and how do we define the disease VHS?

Olesen, Niels Jørgen ; Madsen, Sanne ; Einer-Jensen, Katja ; Skall, Helle Frank ; Lorenzen, Niels
Presented at:
7th International Symposium on Viruses of Lower Vertebrates

Type: Conference abstract for conference

Status: Published     |    Year: 2007

2006
 

Antiviral activity of Small interfering RNAs: Specificity testing using heterologous virus reveals interferon-related effects overlooked by conventional mismatch controls

Schyth, Brian Dall ; Lorenzen, Niels ; Pedersen, Finn Skou
in: Virology, vol: 349, issue: 1, pages: 134-141

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2006     |    DOI: https://doi.org/10.1016/j.virol.2006.01.009

 

Expression of the glycoprotein of viral haemorrhagic septicaemia virus (VHSV) on the surface of the fish cell line RTG-P1 induces type 1 interferon expression in neighbouring cells

Acosta, F. ; Collet, B. ; Lorenzen, Niels ; Ellis, A.E.
in: Fish & shellfish immunology, vol: 21, issue: 3, pages: 272-278

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2006     |    DOI: https://doi.org/10.1016/j.fsi.2005.12.006

 

Genetic stability of the VHSV consensus sequence of G-gene in diagnostic samples from an acute outbreak

Einer-Jensen, Katja ; Ahrens, Peter ; Lorenzen, Niels
in: Bulletin of The European Association of Fish Pathologists, vol: 26, issue: 2, pages: 62-67

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2006

 

Monitoring of the immune system in fish and shellfish

Lorenzen, Niels ; Evensen, O. ; Cunningham, C. ; Scapigliati, G. ; Alvarez, M.C. ; Roch, P. ; Wiegertjes, G. ; Buchmann, K. ; Adams, A.
in: Bulletin of The European Association of Fish Pathologists, vol: 26, issue: 1, pages: 48-49

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2006

2005
 

DNA vaccines for aquacultured fish

Lorenzen, Niels ; LaPatra, S.E.
in: Revue Scientifique Et Technique-office International Des Epizooties, vol: 24, issue: 1, pages: 201-213

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005

 

Genotyping of the fish rhabdovirus, viral haemorrhagic septicaemia virus, by restriction fragment length polymorphisms

Einer-Jensen, Katja ; Winton, J. ; Lorenzen, Niels
in: Veterinary Microbiology, vol: 106, issue: 3-4, pages: 167-178

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005     |    DOI: https://doi.org/10.1016/j.vetmic.2004.12.008

 

Kinetics of Mx expression in rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar L.) parr in response to VHS-DNA vaccination

Acosta, F. ; Petrie, A. ; Lockhart, K. ; Lorenzen, Niels ; Ellis, A.E.
in: Fish & shellfish immunology, vol: 18, issue: 1, pages: 81-89

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005

 

Parallel phylogenetic analyses using the N, G or Nv gene from a fixed group of VHSV isolates reveal the same overall genetic typing

Einer-Jensen, Katja ; Ahrens, Peter ; Lorenzen, Niels
in: Diseases of Aquatic Organisms, vol: 67, issue: 1-2, pages: 39-45

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005

 

Time course study of in situ expression of antigens following DNA-vaccination against VHS in rainbow trout (Oncorhynchus mykiss Walbaum) fry

Lorenzen, Ellen ; Lorenzen, Niels ; Einer-Jensen, Katja ; Brudeseth, B. ; Evensen, O.
in: Fish & shellfish immunology, vol: 19, issue: 1, pages: 27-41

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005     |    DOI: https://doi.org/10.1016/j.fsi.2004.10.009

2004
 

Evolution of the fish rhabdovirus viral haemorrhagic septicaemia virus

Einer-Jensen, Katja ; Ahrens, Peter ; Forsberg, Roald ; Lorenzen, Niels
in: Journal of General Virology, vol: 85, issue: 5, pages: 1167-1179

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2004     |    DOI: https://doi.org/10.1099/vir.0.79820-0

 

Genotyping of viral haemorrhagic septicaemia virus from worldwide using the non-virion gene

Johansson, Tove ; Einer-Jensen, Katja ; Ahrens, Peter ; Lorenzen, Niels ; Olesen, Niels Jørgen
Presented at:
Symposium on Viruses of Lower Vertebrates

Type: Conference abstract for conference

Status: Published     |    Year: 2004